Spring 2016

Seminars are held on Thursdays in Cullimore Hall. For questions about the seminar schedule, please contact Antai Wang.


Date: March 3, 2016

Speaker: Zhigen Zhao
Department of Statistics,
Temple University

University Profile

Title: "A New Approach to Multiple Testing of Grouped Hypotheses"

Abstract:

A new approach to multiple testing of grouped hypotheses controlling false discoveries is proposed. It decomposes a posterior measure of false discoveries across all hypotheses into within- and between-group components allowing a portion of the overall FDR level to be used to maintain control over within-group false discoveries. Numerical calculations performed under certain model assumption for the hidden states of the within-group hypotheses show its superior performance over its competitors that ignore the group structure, especially when only a few of the groups contain the signals, as expected in many modern applications. We offer data-driven version of our proposed method under our model by estimating the parameters using EM algorithms and provide simulation evidence of its favorable performance relative to these competitors. Real data applications have also produced encouraging results for the proposed approach.