NJIT Applied Mathematics Colloquium
Friday, November 11, 2011, 11:30am
Cullimore Lecture Hall II
New Jersey Institute of Technology
A mathematical modeling study of neutrophil dynamics in response
to chemotherapy and G-CSF
Michael Mackey
McGill University
We have used a mathematical model of the combined dynamics of the
hematopoietic stem cells and the differentiated neutrophil progeny to
examine the effects of periodic chemotherapy in generating neutropenia,
and the corresponding response of this system to granulocyte colony
stimulating factor given to counteract the neutropenia. We find that
there is a significant period of chemotherapy delivery that induces
resonance in the system (at a period twice the average neutrophil
lifespan from commitment to death) and a corresponding neutropenia,
suggesting that myelosuppressive protocols should avoid this period to
minimize hematopoietic damage. The response to G-CSF is highly
variable. I will discuss these results as well as extensions of this
research currently underway.
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